New Frontiers In Functional Medicine

Dr. Michael Roizen is an extraordinarily well-read, well-researched, and experienced physician in the field of longevity medicine. He dates his first interest in the field back to 1979 as head of an intensive care unit, when he recognized that patients who were biologically younger dramatically reduced their risk for post-operative disease and death. Since then, he has worked tirelessly in many ways to help individuals get physically and mentally younger, improving the lives of patients and documenting millions of dollars of savings per year in employee healthcare costs at Cleveland Clinic. In our conversation, he shares his lifestyle-forward approach, one that sits well alongside the Younger You program. Tune in to find out the importance of “posse, purpose, play, and locus of control,” how you can be your own genetic engineer, his take on emerging anti-aging interventions, and much more. As Dr. Roizen reminds us, it’s never too late to start – “until you’re six feet under, it ain’t too late to do this.” -Dr

Why are we often resistant to tackling stress and preprogrammed thought patterns? It’s a curious phenomenon that occurs even in those of us who really know the central role these psychological factors play in health, disease, and even aging. That’s why I'm thrilled to interview resilience expert Dr. Stephen Sideroff. After all, a full 25% of the bio-age clock we used in our clinical study is driven by epigenetic patterns on stress-related genes. If you’re looking for the right motivation or framework to begin your own journey into stress resilience, or even if you need that next-level exploration of what really makes you tick psychologically and how you can truly optimize your functioning on all levels, you’ll want to hear what Dr. Sideroff has to say. For practitioners, you’ll discover an excellent intervention to add to your functional medicine and healthy aging toolkit. Listen in, and let us know what you think with ratings, reviews, and emails! Thanks so much for your time -- and enjoy! - DrKF

In this New Frontiers in Functional Medicine® podcast, Dr. Tom Fabian delivers a well-justified challenge to our current thinking and a chance to build a more nuanced approach that will improve patient results around the topic of hydrogen sulfide, a compound that we have typically thought of as the “problem child” behind certain difficult SIBO cases. However, there is a LOT more to know about it, such as its ability to convert to potent antioxidant compounds, and its therapeutic roles in cardiovascular and metabolic disorders (diabetes and NAFLD), neurodegenerative disorders, and more. But how do we start to both broaden and nuance our approach to assessing hydrogen sulfide status? And what interventions can not only supply the substrates for beneficial hydrogen sulfide production, but also help achieve that all-important balance between too little and too much. Listen in to find out, and let us know what you think! ~DrKF

Functional medicine providers are well versed in addressing the myriad manifestations of autoimmune disease, but while our success rates are remarkably high, we still aren’t always able to help everyone using current toolsets (labs, sophisticated elimination diets, gut protocols, and so on). Enter Mymee, a digital app and coaching platform that helps plug that gap – this sophisticated tool helps identify elusive trigger foods and lifestyle factors that may still be contributing to an individual’s disease process. Mymee’s work with COVID long-haul patients and the Mount Sinai post-COVID treatment center (long-COVID is highly autoimmune-related) is impressive and especially relevant for clinicians and patients alike. Some fascinating patterns are emerging from their long-COVID patient data that feed directly back into how to approach these cases differently. I am sure you will find this as interesting and useful a conversation as I did! Please review New Frontiers wherever you hear my voice and let us know what

It’s always a pleasure to tap into Dr. Raffaele’s brain, and in this podcast he doesn’t disappoint. In fact, his practical contextualization of where we are with anti-aging medicine might just be one of the smartest you’ve heard yet. What is truly remarkable about Dr. Raffaele is not just his grasp of the field both scientifically and clinically, but his ability to apply a nuanced approach that is tailored to each individual patient. After all, as he eloquently points out, we must first figure out which of the many components of aging needs improvement or correction, then target our approach accordingly. The simplicity of that statement belies his firm grasp of the complex landscape of anti-aging assessments and interventions, as you’ll see. One of the important topics that surfaced in our conversation is the role of telomere length. Dr. Raffaele has been measuring telomeres in study cohorts and in his patient population for well over a decade. Has looked at well over 2,000 telomere length measurements, man

I am always excited to share new and practical ways to bring Younger You principles to your dinner table and/or clinical practice. And this podcast is especially exciting where Jill Sheppard Davenport and I dive into using broths and tonics as health-promoting and healing foods. Yes, these have been part of our natural medicine toolbox for eons, but we discuss a new spin on this ancient medicine and turn up the volume on superfood and epinutrient ingredients for their myriad health benefits, including bio age reversal properties. We also address important concerns around the potential for bone to harness lead and other toxic metals – so important, we actually researched this very question ourselves, cooking broth from various bone sources and sending it all to the lab for thorough testing. You’ll be relieved by what we discovered (we were!). If you’re intrigued to learn more and start cooking up your own amazing combinations, preorder your copy of our new book, Better Broths and Healing Tonics today! We hav

Are we getting enough nutrients from our diet? And why do nutrient deficiencies persist even in those of us who are putting a lot of attention to what we're eating? Join me and Chris Kresser as we dive into all things nutrient insufficiencies on this episode of New Frontiers. Chris is the founder of the Kresser Institute and the co-founder of the California Center for Functional Medicine. He’s the bestselling author of The Paleo Cure and Unconventional Medicine and a highly respected clinician in our space. We talk about the inadequacies of RDAs, the latest statistics on nutrient insufficiencies, the importance of nutrient bioavailability and nutrient synergy and why taking supplements on top of a really poor diet is not going to help. We also marvel at the wonders of magnesium, the interplay between vitamins D, K2 and A, and calcium plus so much more! It is a conversation filled with clinical pearls and practical implications, so get ready to take notes and tune in! ~DrKF

Many of us in the functional medicine space are thinking about Akkermansia: what exactly makes this gut bug a keystone strain for health and longevity? I am excited to tackle this with a founder of Pendulum Therapeutics, Colleen Cutcliffe, PhD, an excellent scientist and a leader in biotech. Her passion to help her daughter, and many others, overcome food sensitivities inspired Colleen to use biotech and research to develop products that have the efficacy of a drug, but the safety of a probiotic. We cover it all, and then some! Enjoy, and let me know what you think. ~DrKF

Folks, WOW — what a great conversation on all things hormone testing with Dr. Laura Neville from Doctor’s Data! We share the same alma mater, National University of Natural Medicine, as well as extensive experience in clinical lab testing, so had lots to talk about! On this episode of New Frontiers, we discuss what different testing methods tell us about patient’s hormone status, which specimens are best for monitoring hormone replacement therapy and non-HRT interventions, why high dose progesterone carries risks, and what makes liquid urine testing stand out from the rest. Dr. Neville shares many clinical pearls from her experience reviewing thousands and thousands of tests with physicians from around the world. You’ll absolutely want to bookmark for future reference! Thanks for listening and please share, comment, and leave us a starred review if you wouldn’t mind! ~DrKF

As a longevity aficionado, I am so excited to be talking to Dr. Morgan Levine in this episode of New Frontiers! Renowned for her research on the science of biological aging, Dr. Levine specifically uses bioinformatics to quantify the aging process. She's played a vital role in developing and retraining several well-published bio age clocks, including the PhenoAge and Horvath clocks, making them much more reliable. Needless to say, I’m a big fan! Morgan and I dive into the fascinating science behind her new book, True Age: Cutting-Edge Research To Help Turn Back The Clock, and cover loads of important topics such as vetting bio age clocks, the role of the DNA methylome, how standard labs such as CBCs and CMPs can be used to calculate bio age, the controversial debate around immortality, challenges of applying the Yamanaka factors in clinical practice, how racial disparities affect biological aging – and believe me, so much more! I hope you’ll enjoy this thrilling conversation as much as I did, and please give

Eating for longevity. A topic I’m very passionate about and one that has received incredible attention lately. How much protein should we eat to live longer? What about ketones, carbohydrates, and blood sugar spikes? Where does fasting fit in all of this? And what physical activity confers the most benefit for our healthspan? On this episode of New Frontiers, I pose all of these questions and more to one of the most brilliant minds in longevity science – Dr. Valter Longo. I’m so excited to have him as my guest once again – his grasp on the longevity literature is extraordinary, as is his immense contribution to this growing body of research. Dr. Longo and I discuss the fasting-mimicking diet, biological aging, macronutrient targets, the lifestyle pillars of centenarians, and much, much more. It was such a fun (and research-packed)conversation, just wait until you get your ears on it! As always, I would appreciate a thumbs up and a kind review wherever you listen to New Frontiers. - DrKF

What do we know about using specific probiotics for different health conditions? And is it time to move away from broad-spectrum probiotics and into condition-specific strains? With an explosion of new research on probiotics and a recent change in nomenclature, it’s easy to get confused. In this episode of New Frontiers, I lean on Dr. Noelle Patno’s extensive research knowledge to tease apart the science on probiotics. Dr. Patno holds a PhD in Molecular Metabolism and Nutrition and has designed and monitored clinical trials on microbiome and immune health. Together, we dive into the latest evidence on therapeutic uses of specific probiotic strains, including Lactobacillus rhamnosus GR-1, for women’s health and other conditions. Dr. Patno also shares excellent pearls on dosing, duration, delivery methods and antibiotic resistance. Many thanks to Noelle and the team at Metagenics for always leading the way and researching interventions. Appreciate you listening, sharing, and commenting, and always, thanks for s

Hormone therapy is still a highly controversial topic, fraught with lots of emotion, fear, and misleading information. And let me tell you: am I glad to be having a deep dive into the literature with my colleague and friend, the very brilliant Dr. Doreen Saltiel from Precision Analytical. She’s been practicing medicine for 40 years and preventative cardiology for more than 25 years. With advanced training in endocrinology as well as metabolic, anti-aging, and nutritional medicine, Dr. Saltiel is a leading expert on male and female hormone health. In this episode of New Frontiers, she brings her talent of dissecting the scientific evidence on testosterone deficiency and shares excellent clinical pearls to guide both physicians and patients in making decisions around hormone therapy. Folks, you’ll want to bookmark this one and save the show notes. Thanks for reading, sharing, and commenting! ~DrKF

Folks, in this exciting episode of New Frontiers we touch upon topics very close to my heart – genetics, epigenetics, kids, and why the heck they are so hard to raise! Brilliant professor of psychology and research scientist Dr. Danielle Dick shares guilt-banishing parenting strategies and her incredibly liberating research findings on genetics, temperaments, and child development. As an award-winning expert with over 350 scientific publications, Dr. Dick does an excellent job dispelling some deeply-rooted parenting myths and provides evidence-based approaches to understanding children and supporting their development. I can’t wait to get my hands on her new book The Child Code which contains many awesome resources and practical tips, including questionnaires on children’s temperaments and their genetically-influenced dispositions. To all the parents and caregivers out there – this one’s for you! Please share and leave a review to let me know what you think! ~ DrKF

Interest in therapeutic use of psychedelics has grown exponentially in recent years. And with recent studies showing these miraculous molecules help with depression, anxiety, and substance abuse, is it any wonder the p-word is on everyone’s lips? In this unique episode of New Frontiers, the fantastic Dr. Austin Perlmutter guest hosts and interviews renowned psychedelics researcher Dr. Anthony Bossis, clinical assistant professor of psychiatry at NYU and the NYU Center for Psychedelic Medicine. With decades of experience in psychedelic and palliative care research, Dr. Bossis shares an evidence-based deep dialogue on meaning-making, spirituality, and end-of-life care. Tune in to learn how psilocybin can lower depression, anxiety, and end-of-life suffering, the appropriate intervention steps to avoid “bad trips,” what cancer patients define as their most meaningful experiences – and so, so much more. It’s a podcast packed with powerful insights on the human race’s quest for meaning and finding our true selves i

We are living in times of great medical discoveries and advancements and today I am thrilled to talk about a relatively unknown structure: the endothelial glycocalyx (EGX). EGX can profoundly affect overall health – after all, you can’t have healthy organs and tissues if blood vessels are not healthy. Today on New Frontiers, I am joined by Dr. Kristine Burke a board certified family, sports and functional medicine physician and medical director for Help Your Diabetes Sacramento, where we discuss the full breadth of EGX functions and why it’s critical for cardiovascular health and so much more. Dr. Burke shares her exciting clinical experience and impressive findings from her case study series using Arterosil for plaque regression in some of her toughest patients. It’s a fascinating and enlightening conversation, so tune in and get ready to take some notes! Thanks for listening, and your support of New Frontiers. -DrKF

With an ongoing pandemic that doesn't abate, is it any wonder immune health is on everyone's mind? As we adapt to these unprecedented times, the interest in supporting immunity has skyrocketed. So, I couldn't wait to interview my dear friend and long-term colleague, Romilly Hodges. With her new book Immune Resilience just out, I'm thrilled to share Romilly's exciting pearls on immune health on New Frontiers. You may know Rom from her time as Nutrition Programs Director at our clinic and her work on our Methylation Diet & Lifestyle program, now known as Younger You. Romilly is all that, and so much more: also a CNS, IFMCP, and vastly published author in several peer-reviewed journals. In this very special episode, we discuss the role of the microbiome in infection defense and immune system training, the effects of nature exposure, the ongoing pandemic and immune system development, immune tolerance and micro-exposures, and how sleep affects vaccine efficacy. It’s a lot! Romilly also reveals strategic multifa

Folks, I'm thrilled to be back once again with my friend and colleague, Dr. Tom Fabian - leading functional nutrition practitioner trained in the molecular biology of aging. Together with his training and experience as the clinical laboratory consultant for Diagnostic Solutions Lab, Dr. Fabian shares a wealth of practical applications for microbiome research in functional medicine and clinical settings. In this episode, we explore key microbial species for longevity and how to boost their levels, inflammaging of the microbiota, often-missed leaky gut clues on GI-MAP reports, the small intestine as a key site for immune tolerance, how microbiota influence epigenetics, and much more. It’s truly exciting to learn from his extensive research expertise in the role of the human microbiome in health, disease, and aging, so make sure you get ready to take notes and bookmark this page – you’ll want to come back for more! Thanks for listening, and leave us a review wherever you listen to New Frontiers! ~DrKF

Sleep – we spend a third of our lives doing it, we know it is a powerful longevity tool, yet we continue to skimp on it. I know from personal experience – improving my sleep after struggling for years was a total game-changer. And in this episode of New Frontiers, I’m joined by Dr. Sara Mednick, world-renowned sleep scientist, professor of psychology at the University of California, and director of the Sleep and Cognition Lab to discuss her exciting research findings and new lexicon for understanding stress. Together we explore why aligning sleep with the nervous system’s downstate is more important than sleep duration for optimal restoration and longevity – AND how you can use heart-rate variability to measure restore function. We also talk about green exercise, harnessing the power of dreams, setting health boundaries, the connection between meal timing and melatonin, and WOW -- so much more. This one is a gem-packed session for sure, so get ready to take some notes and get inspired! And if you don’t mind

Reversing biological age by just one year can save $38 trillion of public health funding. Read that again. $38 TRILLION. And by now, you probably know in my new Younger You book, I walk through exactly how to reverse your biological age by over three years through nutrition and lifestyle. But writing a book is not enough, and I’m really excited to bring an easy-to-follow digital program accessible from anywhere in the world. And I couldn’t have done it without Suggestic, the innovative health tech company powering the 3YY digital program. In this episode of New Frontiers, I share the ins and outs of this turnkey digital program with the potential to revolutionize personalized nutrition delivery and optimize health at scale. Join me for an intimate chat with my good friends and colleagues from Suggestic, Victor Chapela and Erica Sanders, and discover how we translate the multi-modal clinical trial intervention into a digital program everyone can access by combining lab testing, supplementation and one-to-one