Lupus Science And Medicine Podcast

Duane Peters from the Lupus Foundation of America interviews Dr Jim Oates from the Medical University of South Carolina and Ralph H. Johnson VA Medical Center in Charleston, USA. They discuss his paper on developing risk prediction models in lupus nephritis to predict outcomes at the point of diagnosis, which can be used as a decision support tool to help inform treatment strategies for patients. Access the paper here: https://lupus.bmj.com/content/8/1/e000489

Duane Peters from the Lupus Foundation of America interviews Dr Ronald von Vollenhoven, one of LSM's Editors-in-Chief, about the highlights of the 14th International Congress on Systemic Lupus Erythematosus (LUPUS 2021) and the 6th International Congress on Controversies in Rheumatology and Autoimmunity (CORA). These events were held jointly as a virtual congress on 6-9 October 2021 (https://lupus2021.kenes.com) and showcased the best clinical, biological, and translational advances in the field of SLE and autoimmunity.

Duane Peters from the Lupus Foundation of America interviews Dr Jill Buyon, one of LSM's Editors-in-Chief, and Dr Philip Carlucci from New York University in the USA, a previous recipient of the LFA's Gina M. Finzi Memorial Student Summer Fellowship. They discuss their recent paper on the safety of kidney biopsies in patients with SLE enrolled in the Accelerating Medicines Partnership in the USA, which aims to identify potential targeted treatments for lupus nephritis. Access the paper here: https://lupus.bmj.com/content/8/1/e000522

Duane Peters from the Lupus Foundation of America interviews the Lupus Science & Medicine Editors-in-Chief, Professor Jill Buyon and Professor Ronald van Vollenhoven. They discuss the recent release of LSM's first Journal Impact Factor™, explaining how it has been calculated, and what it means for the journal, its authors and readers. Access all the LSM journal metrics: https://lupus.bmj.com/pages/top-cited-articles/ and https://lupus.bmj.com/pages/about/.

Duane Peters from the Lupus Foundation of America interviews Dr Stephen Balevic, Dr Rachel Randell and Professor Laura Schanberg from Duke University in the USA. They discuss the advantages and challenges of designing and implementing self-controlled clinical trials for paediatric lupus patients in a home setting, based on their experience of conducting the Individual Patient Exposure and Response in Pediatric Lupus (iPERSONAL) trial. Could this be a way to effectively deliver clinical trials in a post-pandemic world? Access the paper here: https://lupus.bmj.com/content/8/1/e000494

Duane Peters of the Lupus Foundation of America follows up with Professor Ronald van Vollenhoven of the Amsterdam University Medical Centers to discuss the highlights of the lupus research presented at the EULAR 2021 eCongress, which was held virtually on 2-5 June 2021. EULAR Congress website: https://congress.eular.org/index.cfm EULAR 2021 abstracts: https://ard.bmj.com/content/80/Suppl_1

Duane Peters from the Lupus Foundation of America interviews Professor Eric Morand from Monash University in Australia and Dr Raj Tummala from AstraZeneca in the USA about phase II and III trials of the human monoclonal antibody anifrolumab. Their pooled analysis of data from the MUSE, TULIP-1 and TULIP-2 trials showed that, in addition to demonstrating efficacy in adults with moderate to severe systemic lupus erythematosus (SLE), anifrolumab was generally well tolerated with an acceptable safety profile. Anifrolumab was associated with an increased incidence of herpes zoster and respiratory tract infections and a lower reported rate of SLE worsening. This positive benefit–risk profile means that anifrolumab is a potential new treatment option for SLE. Access the paper here: https://lupus.bmj.com/content/8/1/e000464

Duane Peters from the Lupus Foundation of America interviews Dr Susan Manzi from the Allegheny Health Network and Kathleen Arntsen from the Lupus and Allied Diseases Association, both based in the USA, about the Addressing Lupus Pillars for Health Advancement (ALPHA) Project. The ALPHA Project is the first global initiative to identify, prioritise and address top barriers in lupus impacting diagnosis, care, treatment and research. The diverse team includes lupus experts, clinicians, researchers, industry representatives, advocacy organisations and people with lupus, and there is a specific focus on the patient perspective. Access the paper here: https://lupus.bmj.com/content/8/1/e000433

Duane Peters of the Lupus Foundation of America follows up with Professor Ronald van Vollenhoven of the Amsterdam University Medical Centers to discuss the highlights of the 10th Annual Meeting of the Lupus Academy, which was held virtually on 16-18th April 2021. Lupus Science & Medicine is the official journal of the Lupus Academy and the abstracts from the event have been published as a supplement to the journal. Lupus Academy website: lupus-academy.org/ Lupus Academy 2021 abstracts: lupus.bmj.com/content/8/Suppl_1

Duane Peters of the Lupus Foundation of America interviews Professor Ronald van Vollenhoven of the Amsterdam University Medical Centers about the 10th Annual Meeting of the Lupus Academy, which will be held virtually from 16-18th April 2021. As well as his role as co-Editor-in-Chief of Lupus Science & Medicine, Professor van Vollenhoven is a member of the Lupus Academy Steering Committee and has been involved in the planning and development of the 10th Annual Meeting. Participation in the event is free but registration is required. Lupus Science & Medicine is the official journal of the Lupus Academy and the abstracts from the event have been published as a supplement to the journal. Lupus Academy website: https://lupus-academy.org/ Lupus Academy 2021 abstracts: https://lupus.bmj.com/content/8/Suppl_1

Duane Peters from the Lupus Foundation of America interviews Dr Ashira Blazer from New York University, USA, and Dr Ida Dzifa Dey from the University of Ghana in Accra, Ghana, about the associations between apolipoprotein L1 genetic polymorphisms and disease outcomes among SLE patients in Ghana. Access the paper here: https://lupus.bmj.com/content/8/1/e000460

Duane Peters from the Lupus Foundation of America interviews Ms Meghan Angley and Dr Sam Lim from Emory University in Georgia, and Dr Megan Clowse from Duke University in North Carolina, about infertility and reproductive injustice in African-American women with systemic lupus erythematosus. Access the papers here: https://lupus.bmj.com/content/7/1/e000439 https://lupus.bmj.com/content/7/1/e000455

Duane Peters from the Lupus Foundation of America interviews Dr Pintip Ngamjanyaporn and Dr Nantakarn Pongtarakulpanit from Mahidol University in Bangkok, Thailand, about their study on the short term efficacy and safety of rituximab biosimilar in refractory lupus. Access the paper here: https://lupus.bmj.com/content/7/1/e000442

Duane Peters from the Lupus Foundation of America interviews Dr Diane Apostolopoulos and Dr Eric Morand from Monash Health in Australia about their study into the prevalence of metabolic syndrome in patients with SLE and the potential associations between the use of glucocorticoids and specific cardiovascular risk factors. Access the paper here: https://lupus.bmj.com/content/7/1/e000436

Duane Peters from the Lupus Foundation of America interviews Dr Manuel Francisco Ugarte-Gil from Peru and Dr Joan Merrill and Dr Anca Askanase from the USA about their study evaluating the use of LFA-REAL clinician-reported and patient-reported outcomes in establishing disease severity in SLE. Access the paper here: https://lupus.bmj.com/content/7/1/e000419

Duane Peters from the Lupus Foundation of America interviews Dr May Choi and Dr Peter Schur from the Lupus Program at Brigham and Women's Hospital in Boston. They discuss the use of the ANA assay for the diagnosis and classification of systemic lupus and other autoimmune rheumatic diseases. Access the paper here: https://lupus.bmj.com/content/7/1/e000431

Duane Peters of the Lupus Foundation of America talks to Elisabet Svenungsson and Helena Idborg from Karolinska Institutet about their published paper: Kynurenine pathway is altered in patients with SLE and associated with severe fatigue. Access the paper here: http://doi.org/10.1136/lupus-2017-000254

Duane Peters of the Lupus Foundation of America talks to Elisabet Svenungsson and Helena Idborg from Karolinska Institutet about their published paper:TNF-alpha and plasma albumin as biomarkers of disease activity in systemic lupus erythematosus. Access the paper here: http://doi.org/10.1136/lupus-2018-000260

Duane Peters from the Lupus Foundation of America interviews Dr Jill Buyon, Professor of Rheumatology at New York University School of Medicine and co-Editor-in-Chief of Lupus Science & Medicine. Dr Buyon presents an overview of the journal's strengths and unique features, the editorial review process, and why authors should consider submitting their next lupus paper to LSM. Learn more about the journal at lupus.bmj.com

Lupus Science & Medicine Associate Editor Professor Lars Ronnblom talks to Professor Joan T. Merrill from the Oklahoma Medical Research Foundation about her published paper: Anifrolumab effects on rash and arthritis: impact of the type I interferon gene signature in the phase IIb MUSE study in patients with systemic lupus erythematosus. Access the paper here: https://lupus.bmj.com/content/5/1/e000284