Nature Podcast

CRISPR-based gene editing has revolutionized modern biology, but these tools are unable to access the DNA that resides inside mitochondria. Researchers are eager to access and edit this DNA to understand more about the energy production and the mutations that can cause incurable mitochondrial diseases.Because CRISPR can’t help with these problems, researchers have been looking for other ways to precisely edit the mitochrondrial genome. And the past few years have brought some success — if researchers can make editing safe and accurate enough, it could eventually be used to treat, and even cure, these genetic conditions.This is an audio version of our Feature: Faulty mitochondria cause deadly diseases — fixing them is about to get a lot easier Hosted on Acast. See acast.com/privacy for more information.

00:46 Martian ‘micro-lightning’The sounds of ‘micro-lightning’ have been recorded by NASA’s Perseverance rover, ending a long search for the phenomenon on Mars. A lack of suitable equipment has made it difficult to gather evidence of lightning on the red planet, but a team of researchers realized that a microphone on Perseverance should be able to pick up the characteristic sounds of electrical discharges. In total they found 55 such examples, along with signs of electrostatic interference indicative of the phenomenon. They dubbed the electric bursts ‘micro-lightning’, as they are far smaller than the lighting seen on Earth, due to the thin Martian atmosphere. The team believe this finding could help better understand Martian chemistry and how best to design equipment to explore the planet’s surface.Research Article: Chide et al.News and Views: Is there lightning on Mars?11:03 Research HighlightsHow the biology of male seahorses’ brood pouches appears similar to mammalian pregnancy— plus, why Neande

00:45 A molecule that delivers insulin through the skinResearchers have developed a skin-permeable polymer that can deliver insulin into the body, which they say could one day offer an alternative to injections for diabetes management. The skin’s structure presents a formidable barrier to the delivery of large drugs but in this work a team show that their polymer can penetrate though the different layers without causing damage. Insulin attached to this polymer was able to reduce blood glucose levels in animal models for diabetes at a comparable speed to injected insulin. While further research is required on the long-term safety of this strategy, the team hope it could offer a way to non-invasively deliver other large-molecule drugs into the body.Research Article: Wei et al.09:23 Research HighlightsHow extreme drought may be humanity’s biggest challenge after a huge volcanic eruption — plus, turning a bacterium into a factory for a colour-changing pigmentResearch Highlight: Volcano mega-eruptions le

Yoshua Bengio, considered by many to be one of the godfathers of AI, has long been at the forefront of machine-learning research . However, his opinions on the technology have shifted in recent years — he joins us to talk about ways to address the risks posed by AI, and his efforts to develop an AI with safety built in from the start. Nature: ‘It keeps me awake at night’: machine-learning pioneer on AI’s threat to humanity Hosted on Acast. See acast.com/privacy for more information.

00:45 A coronal mass ejection from a distant starResearchers have detected what they say is the strongest evidence yet of a coronal mass ejection (CME) coming from a star other than our Sun. CMEs are massive bursts of fast-moving plasma that can be detected thanks to the characteristic radio signal they produce. However, despite decades of searching, these signals have only been identified from the Sun. Now a team has identified a similar signal coming from a distant star in the Milky Way. They hope their discovery will lead to better understanding of the impact these colossal events might have on the atmospheres of exoplanets, and their chances of being habitable.Research Article: Callingham et al.12:28 Research HighlightsVideo footage of a devastating earthquake provides a first-of-its-kind glimpse of a dramatic ground rupture — plus, a flock of comets seen outside our Solar System.Research Highlight: Single video camera tells the story of deadly Myanmar quakeResearch Highlight: A host of ‘ex

00:45 The debate around NanotyrannusA hotly debated species of dinosaur, assumed by many to be a juvenile T. rex, is actually a separate species, according to new research. Nanotyrannus was a dinosaur anatomically similar to T. rex, but about a tenth of the size, leading many to argue it was a young version of the iconic species. However, examination of the limb bones of a well-preserved Nanotyrannus fossil suggests it was close to finishing its growth and so would never become as large as a T. rex, leading the authors to argue that it is, in fact, a different species.Research Article: Zanno and NapoliNews and Views: T. rex debate settled: contested fossils are smaller rival species, not juvenilesNews: ‘Teenage T. rex’ fossil is actually a different speciesVideo: Hotly debated dinosaur is not a tiny T. rex after all08:46 Research HighlightsAn artificial ‘neuron’ could pave the way to build a brain-inspired computer — plus, how bats buck the trend by hunting prey their own size.Research Hig

00:47 How bowhead whales live so longResearchers have uncovered a protein that enhances DNA repair and may explain how bowhead whales can live more than 200 years. The protein, cold-induced RNA-binding protein, was shown to enhance repair of double stranded DNA breaks, a particularly troublesome kind of damage. The team showed that this protein could also extend the lives of Drosophila flies and enhance repair in human cells. More needs to be understood about how this protein works, but the researchers hope that it could, one day, help prevent cancer and ageing in humans.Research Article: Firsanov et al.News: This whale lives for centuries: its secret could help to extend human lifespan11:22 Research HighlightsA precise way to grow crystals, with lasers — plus, the specialist organ that allows stinkbugs to protect their eggs from wasps.Research Highlight: How to grow crystals when and where you want themResearch Highlight: Stinkbug ‘ear’ actually hosts parasite-fighting fungi13:3

Advice on how to get good sleep is everywhere, with the market for sleep aids worth more than US$100 billion annually. However, scientists warn that online hacks and pricey tools aren’t always effective, and suggest that lessons learnt about the workings of a network of biological clocks found in the human body could ultimately lead to improved sleep.This is an audio version of our Feature: How to get the best night’s sleep: what the science says Hosted on Acast. See acast.com/privacy for more information.

00:48 How hunger, hormones and aggression interact in mouse brainsResearchers have uncovered the neural mechanisms that underlie an aggressive behaviour in mice prompted by hunger and hormonal state. Virgin female mice can become aggressive towards mouse pups when they are food deprived, but it seems that the relevant amounts of pregnancy hormones, oestrogen and progesterone, also played a role. By investigating the neurons involved, neuroscientists showed how hunger and hormones are integrated by the brain to lead to aggressive behaviour. This could help researchers understand more about how multiple stimuli are interpreted by the brain, something much harder to study than single stimulus effects.Research Article: Cao et al.09:35 Research HighlightsThe overlooked environmental costs of wastewater treatment facilities — plus, an ancient communal hunting system that lasted well into the eighteenth century.Research Highlight: Wastewater treatment produces surprising amounts of greenhouse gasesResearch

00:46 A multi-variant avian flu vaccine that could enhance pandemic preparednessA vaccine capable of protecting against multiple strains of avian influenza virus might be a step closer, according to new research. The H5 subtype of avian influenza viruses has spilled over into mammals and is particularly concerning to researchers because of the risk that one of its variants may evolve to cause a pandemic. But because there are multiple variants of these viruses, it has been hard to pre-prepare vaccines. Now, a team has used information on how H5 viruses changed over time to design a vaccine that in animal studies provided protection against different H5 variants. They hope their approach could be applied to create stockpiles of a vaccine that could be used in the event of a pandemic, regardless of the variant that causes it.Research Article: Kok et al.10:53 Research HighlightsMaking muon beams without a huge particle accelerator — plus, the bats hunting migrating birds in mid-air.Research Highlight: Portable m

00:48 The stereotypes hidden in Internet imagesStereotyped assumptions about women’s ages and their perceived job suitability are enhanced by Internet imagery, according to new research. A study of hundreds of thousands of online images shows that women appear younger than men. This stereotype extends to the jobs that people perceive women do, with men being associated with roles such as CEO or head of research, while women were linked to occupations like cook or nurse. The research shows that these biases have been embedded into the training data for AI models and could affect future hiring. The researchers caution that society is at risk of creating a ‘self-fulfilling prophecy’ where these stereotypes shape the real world.Research Article: Guilbeault et al.News and Views: Distorted representations of age and gender are reflected in AI models13:24 Research HighlightsA very hungry planet — plus, how climate change is leading to larger trees in the Amazon.Research Highlight: ‘Rogue’ planet is fa

00:50 How ancient viruses drive modern human developmentResearch suggests that ancient viral-DNA embedded in the human genome is playing a key role in early embryo development. Around 8% of our genome consists of endogenous retrovirus DNA — the remnants of ancient infections, but knowledge of their activity is limited. Now, a team show that these sequences are required for the correct development of lab-derived embryo analogues, and for the switching on of human-specific genes.Research Article: Fueyo et al.News and Views: Ancient viral DNA in the human genome shapes early development10:39 Research HighlightsLonger whale mothers are more likely to give birth to daughters — plus, how the stink of the corpse flower waxes and wanes to attract pollinators.Research Highlight: Big mother whales have more daughters than sonsResearch Highlight: Corpse flowers waft out stinky compounds as fast as landfills do13:05 How heat can fuel DNA computersResearchers have developed a way to use heat to recharg

In April, Robert F. Kennedy Jr held a press conference about rising diagnoses of autism, and said he would soon be announcing a study to find the responsible agent. Although Kennedy said that environmental factors are the main cause of autism, research has shown that genetics plays a bigger part. Also, the rise in prevalence, many researchers say, is predominantly caused by an increase in diagnoses rather than a true rise in the underlying symptoms and traits.Although the US National Institutes of Health (NIH) announced a US$50 million to fund studies on the causes of autism, many researchers were dismayed that these developments seemed to ignore decades of work on the well-documented rise in diagnoses and on causes of the developmental condition.This is an audio version of our Feature: Autism is on the rise — what’s really behind the increase? Hosted on Acast. See acast.com/privacy for more information.

00:48 New insights into tick-borne encephalitisResearchers have identified a key protein that helps tick-borne encephalitis virus enter the brain. In rare cases an infection can lead to serious neurological symptoms, but little was known about how the virus interacts with human cells. Now, a team show that a protein found on the outside of cells plays an important role in infection. In mouse experiments, they show that blocking the ability of the virus to bind to this protein protected the mice from disease. Currently no treatments exist, but the team hopes that this research will ultimately lead to a viable drug for this disease.Research Article: Mittler et al.08:47 Research HighlightsThe squirming robot that speeds up the insertion of an emergency breathing tube — plus, the 10,000-year-old remains that could be the oldest intentionally preserved mummiesResearch Highlight: Soft robot steers itself down the human airwayResearch Highlight: Smoke-dried mummies pre-date Egypt’s embalmed bodies11:2

Science journalist Lizzie Wade’s first book, Apocalypse: A Transformative Exploration of Humanity's Resilience Through Cataclysmic Events explores some of the cataclysmic events that humans have faced through history. Lizzie joined us to discuss what modern archaeology has revealed about these events, and the role these they’ve have played in shaping societies around the world.Apocalypse: A Transformative Exploration of Humanity's Resilience Through Cataclysmic Events Lizzie Wade Harper (2025)Music supplied by SPD/Triple Scoop Music/Getty Images Hosted on Acast. See acast.com/privacy for more information.

00:50 The AI tool that predicts disease riskResearchers have developed an AI tool that can calculate a person’s risk of developing over 1,000 different diseases, sometimes years in advance. The system, called Delphi-2M, was trained to identify patterns of disease progression using 400,000 people's health records from data repository the UK Biobank. This training allowed it to predict someone’s future disease risks, based on their current medical record. While AI health prediction systems do exist, they typically only estimate risks for a single disease — the authors hope that their system could one day save healthcare professionals time and be used to calculate disease burdens at a population level.Research Article: Shmatko et al.News: What diseases will you have in 20 years? This AI makes predictions11:01 Research HighlightsEvidence that refugees hosted by local families integrate better into their adoptive country — plus, the squidgy shirt that can keep wearers cool.Research Highlight: How to

In 2015, the Laser Interferometer Gravitational Wave Observatory (LIGO) facilities in the US directly detected ripples in space-time, known as gravitational waves. These waves were produced by the final spiral of two orbiting black holes that smashed into each other, sending ripples across the Universe.   In this podcast, Benjamin Thompson speaks to Cole Miller from the University of Maryland about the quest to detect gravitational waves, which were first hypothesised by Albert Einstein back in 1916.  Hosted on Acast. See acast.com/privacy for more information.

00:45 Attributing extreme heat events to major energy producersMajor energy producers increased the likelihood and intensity of heatwaves, according to research published in Nature. Using data from an international disaster database, a team developed a methodology to investigate how much anthropogenic climate change had influenced heatwaves. They conclude that many of these events would have been “virtually impossible” without climate change, and that nearly a quarter of the heatwaves recorded from 2000 to 2023 can be directly linked to the greenhouse-gas emissions from individual energy giants.Research Article: Juvé et al.News and Views Forum: Heatwaves linked to emissions of individual fossil-fuel and cement producersNews: Dozens of heatwaves linked to carbon emissions from specific companies10:47 Research HighlightsHow shifting coastal tides may have spurred the rise of the world’s oldest civilization — plus, the liquid crystal lenses that can refocus in a flash.Research Highlight: 

In 2016, Brian Wansink wrote a blog post that prompted scientific sleuths to investigate his work. They found evidence of data manipulation, and, after several news articles and two investigations by his institution, he would found to have committed misconduct, as defined by Cornell University. His work had been used to inform US policy around food, much of which has now been thrown into question.Cases like this are rare, but science is not immune to misconduct. The rise in 'paper mills' — organisations that produce questionable or fake papers that they sell authorships on — has led some to worry that misconduct is on the rise and that a proportion of the scientific literature cannot be trusted.In episode two of Self Correction, we explore how researchers are responding to the problem of research misconduct. We discuss how difficult it is to determine the prevalence of misconduct, and how sleuths, journalists and research integrity institutions are fighting back.This episode was written and produced by N

Raising mosquitoes to tackle disease might sound like an odd concept, but that’s what a facility in Brazil is aiming to do. Millions of mosquitoes are produced there every week, but these insects carry harmless Wolbachia bacteria that curbs their ability to spread deadly human viruses. Nature reporter Mariana Lenharo visited the facility and told us all about her experience in this Podcast Extra.News: This is the world’s largest ‘mosquito factory’: its goal is to stop dengueVideo: Inside a mosquito factorySubscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.