Manifold

Jaan Tallinn is a tech billionaire and founding engineer of Skype who leverages his wealth to mitigate existential risks from artificial general intelligence (AGI). He co-founded the Future of Life Institute and the Centre for the Study of Existential Risk, while making early foundational investments in frontier AI labs like DeepMind andAnthropic.Chapter Markers:00:00 Assessing Current AI Risk Levels03:28 Inside Self-Sustaining AI Scenarios09:10 The Global AI Race Dynamics42:25 Explaining the Techno-Capital Flywheel45:34 Insider Origins of AI Safety56:06 Race Politics and Public Fear01:23:12 Pop Culture, Movies, and Fame01:30:15 Big Questions for Humanity's Future–Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic

Dr. Alex Young, a statistical geneticist and assistant professor in the Human Genetics department at UCLA, joins Steve Hsu to discuss the cutting edge of genomic prediction. They cover his research on polygenic embryo screening in IVF (including the ImputePGTA method), family-based DNA analysis, missing heritability, and the implications of polygenic scores for traits like education and disease. Alex also discusses his recent battles with cancer.https://x.com/AlexTISYoungChapter Markers:(00:00) - Alex Young Bio (06:36) - Biobank Era Genetics (10:49) - Missing Heritability Debate (27:18) - Embryo Selection Controversy (50:32) - Embryo Selection Backlash (53:42) - Mexico City Admixture Study (01:00:13) - Censorship Via Data Access Control (01:05:02) - Battle With Cancer and Circulating Tumor DNA (ctDNA) –Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU

Steve and Alf discuss the Iran War, emphasizing what itreveals about modern missile and anti-missile technology, drones, andthe implications for a US-China conflict in the Western Pacific.Links:https://seekingtruthfromfacts.substack.com/Chapter Markers:(00:00) - Missile War Reality Check (01:49) - How the War Started (04:46) - Iran Outperforms Expectations (06:22) - Why Missile Defense Fails (14:25) - Ceasefire and Hormuz Brinkmanship (19:52) - Nukes and the JCPOA Fallout (33:44) - US Politics and Israel Lobby Aftershocks –Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fel

Richard Ngo is an independent AI researcher and philosopher known forhis work on AGI safety and alignment. He recently resigned fromOpenAI, where he was a member of the Governance team focused onforecasting the capabilities and risks of advanced AI systems. Hisdebut fiction collection is titled "The Gentle Romance: Stories of AIand Humanity", published in December 2025. The book features 22science fiction stories that explore the psychological andsociological impacts of advanced artificial intelligence.On X: @RichardMCNgo(00:00) - Richard Ngo Origins (03:48) - DeepMind vs LLMs (09:24) - OpenAI Futurist and AGI Risk (39:17) - Machine God Tail Risk (45:20) - Weird Futures and Normies (51:28) - Alignment Research and Academia (01:16:25) - Doomers vs Skeptics (01:23:57) - Labs Governance Futures (01:39:37) - Doom Scenarios Society –Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Rese

Matt Southey is an editor for an AI safety organization. He wrote his PhD dissertation on the philosophy of Nick Land. Matt's "A Brief History of Accelerationism" can be found here, and he recommends the second chapter of Crypto-Current as a good introduction to Land's usage of Kant. He and Steve discuss Accelerationism, AI, and Steve's recent meeting with Land in Shanghai.Chapter Markers:(00:00) - Introduction (02:07) - China Trip: Shenzhen, Beijing, Shanghai (03:16) - Tsinghua University: Talent (09:02) - Robotics and AI research (24:01) - Shanghai and Nick Land (35:46) - Land’s Esotericism (37:19) - Accelerationism and Orthogonality (43:01) - Simulation Metaphysics and Physics (54:36) - Dark Enlightenment and Inevitable Complexity –Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the Universi

Recorded live in Shenzhen with Taylor Ogan, the founder and CEO ofSnowbull Capital, which invests in Chinese technology companies.Taylor on X:https://x.com/TaylorOganPrevious episodes with Taylor:https://youtu.be/iehHON07UHI?si=h2c3po5AX9Z9ANaK https://youtu.be/fmjR3me5s_Q?si=sPsMFOdKebEOZXQr(00:00) - Shenzhen is the Technology Capital of the World, with Taylor Ogan (00:53) - Meeting in Shenzhen (02:40) - Greater Bay Area Explained (06:36) - Shenzhen Boom Stories (18:26) - China Tech Reality Check (36:49) - China Tech Leapfrogging (37:52) - Agentic AI on Phones (41:27) - Jobs Wealth and Governance (53:03) - Huawei Ownership and US Pushback –Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and

This is the second episode of our series based on interviews for the documentary film, Dreamers and Doomers, about the SF Bay Area in the last days before AGI. Steve interviews Jesse Hoogland, co-founder and executive director of Timaeus, an AI safety research org working on applications of Singular Learning Theory (SLT) for AI safety. SLT establishes a connection between the geometry of the loss landscape and internal structure in models. This connection is used to develop scalable, rigorous tools for evaluating, interpreting, and aligning neural networks. Jesse is one of the leading young minds in the new generation of AI safety researchers.https://www.jessehoogland.com/(00:00) - Jesse interview at FAR Labs, Berkeley (00:54) - Introduction (01:50) - From Physics to AI Safety (08:36) - AI Is Dangerous (26:08) - Funding, P(Doom), and Futures (56:21) - Trauma and Safety Vibes (01:00:39) - Asymptotic Guarantees Debate (01:03:54) - Mapping the Safety Tribes (01:26:09) - Timelines, AI Pause, and Failure Modes –S

Jeremy Nixon is a prominent AI researcher, entrepreneur, and the co-founder of AGI House, a leading "hacker house" community for artificial intelligence developers in Silicon Valley. He studied Applied Math, Computer Science, and Economics at Harvard and was previously a researcher at Google Brain.This footage was shot for a documentary project, "Dreamers and Doomers," about the SF Bay Area and the dawn of AGI.(00:00) - Dreamers and Doomers: Jeremy Nixon at AGI House – #105 (01:47) - Introduction and Welcome (05:56) - Jeremy Nixon's biography (08:48) - AGI House and collectives (43:59) - AI and Scientific Research (45:52) - Existential Risks and Doom (54:14) - AI and Human Progress (01:26:42) - Job Automation and Society (01:31:35) - Future of AI and Technology –Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoret

Links:Breakneck: China's Quest to Engineer the Futurehttps://www.amazon.com/Breakneck-Chinas-Quest-Engineer-Future/dp/1324106034Dan's 2025 annual letterhttps://danwang.co/2025-letter/Related episodes:Jian Lian on Industrial Maximalism, Manifold Episode #99https://www.manifold1.com/episodes/jian-lian-on-chinas-industrial-policy-and-global-strategy-99(00:00) - Introduction and Welcome (02:14) - Breakneck - Dan's huge book (05:00) - China's Technological and Political Landscape (21:07) - Industrial Maximalism and its Discontents (47:59) - Chinese Researchers in Silicon Valley and Tsinghua (51:09) - Excerpts from Dan's 2025 annual letter (52:56) - China's Market Competition and Innovation (56:34) - AI, Automation, and Future Risks –Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of

Steve and Alf discuss geopolitical events of 2025 and what they expect in 2026.Links:Manifold episode with Han Feizi, Letter From Beijinghttps://www.manifold1.com/episodes/letter-from-beijing-with-han-feizi-72Previous crossover episodes:Weeks Where Decades Happenhttps://www.manifold1.com/episodes/seeking-truth-from-facts-weeks-where-decades-happenAI, China, Tariffs, Geopoliticshttps://www.manifold1.com/episodes/seeking-truth-from-facts-ai-china-tariffs-geopolitics-84(00:00) - Geopolitics 2026, crossover with Seeking Truth From Facts podcast – #103 (02:10) - US-China Economic Tensions (05:45) - Technology and Strategic Shifts (08:48) - Trump's Geopolitical Strategy (17:43) - Middle East Developments (28:41) - US-China Competition and Taiwan (33:44) - Venezuela and International Law –Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the

This is a two-part episode. The first ~30m covers the most important 2025 breakthroughs in polygenic embryo screening, while the second 30m focuses specifically on AI capabilities at the frontier of human knowledge. Both segments make predictions for 2026 and beyond.Links:Chinese billionaires, Philo-semitism, and the Chosen embryos:https://x.com/hsu_steve/status/2000206116823675078My talk from Reproductive Frontiers 2025 in Berkeley:https://www.youtube.com/watch?v=n64rrRPtCa8Previous episodes on frontier AI capabilities in math and theoretical physicshttps://www.manifold1.com/episodes/theoretical-physics-with-generative-ai-101https://www.manifold1.com/episodes/ais-win-math-olympiad-gold-prof-lin-yang-ucla-97Chapter Markers:(00:00) - Introduction (02:22) - Advancements in Polygenic Prediction of Human Traits (03:20) - Polygenic Risk Scores in Healthcare (08:15) - Embryo Selection and IVF (20:37) - Public Perceptions: billionaires and FOMO (31:40) - AI advances in 2025: High end capabilities and use of AI at th

All but the last 20 minutes of this episode should be comprehensible to non-physicists.Steve explains where frontier AI models are in understanding frontier theoretical physics. The best analogy is to a “brilliant but unreliable genius colleague”!He describes a specific example: the use of AI in recent research in quantum field theory (Tomonaga-Schwinger integrability conditions applied to state-dependent modifications of quantum mechanics), work now accepted for publication in Physics Letters B after peer review. Remarkably, the main idea in the paper originated de novo from GPT-5.Links:X discussion - https://x.com/hsu_steve/status/1996034522308026435Companion paper: Theoretical Physics With Generative AI -  https://drive.google.com/file/d/16sxJuwsHoi-fvTFbri9Bu8B9bqA6lr1H/viewPhysics paper - https://arxiv.org/abs/2511.15935 | https://www.sciencedirect.com/science/article/pii/S0370269325008111Related discussion of AI and theoretical physics with Prof. Nirmalya Kajuri (IIT) and Prof. Jonathan Oppenheim (UCL)

Murtaza Hussain is a reporter for Drop Site News, which has brokenimportant stories based on recently obtained Epstein emails. Hussainreports that Epstein had an “extensive relationship with Israeliintelligence, U.S. intelligence and the intelligence agencies of othercountries, as well... He was a dealmaker and a fixer at a very, veryelite level.”Links:Drop Site News series on Epstein and Israelhttps://www.dropsitenews.com/s/epstein-and-israelFormer Israeli spy Ari Ben Menashe on Jeffrey Epsteinhttps://x.com/hsu_steve/status/1994046737040712144(01:08) - Introduction (02:20) - The Mission of Drop Site News (06:00) - Epstein Emails (15:28) - Epstein connections and elite power (35:48) - Epstein and intel agencies (39:54) - Ari Ben Menashe and the Iran Contra Affair (42:21) - Media Censorship and Political Implications (47:33) - The Future of Epstein Investigations –Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously,

Jian Lian is an expert on China's political economy, industrial development, and technological development. He graduated from Peking University with a bachelor's and master's degree in economics. Starting out as an industry analyst at a Chinese investment bank, he participated in the "Made in China 2025" initiative as a Chinese venture capitalist, working for a state-owned fund. He is the author of "The Truth About Capital" 资本的真相 (2016), which contains major predictions about technology, economy, and society in China, most of which have since come true.Jian and Steve discuss the origins of the industrial party movement (discussed in an earlier episode with Kyle Chan), which culminated in the "industrial maximalism" view of development adopted by the PRC government. They also discuss the development of supply chains in China, and the role that US sanctions had in accelerating the Chinese semiconductor industry.Kyle Chan episode:https://www.manifold1.com/episodes/kyle-chan-on-the-future-of-us-china-competition-

Scott Horton is the author of Provoked: How Washington Started the New Cold War with Russia and the Catastrophe in Ukraine. Horton is a libertarian and anti-war activist. He and Steve discuss the Russia Hoax and its connection to American foreign policy, in light of new evidence that has emerged since the first Trump term.Scott’s book: https://www.amazon.com/Provoked-Washington-Started-Catastrophe-Ukraine/dp/1733647376X handle: @scotthortonshow(00:00) - Scott Horton on the Russia Hoax and Ukraine War – #98 (01:49) - Scott Horton's Political Journey (04:55) - The State of Public Awareness and Media (11:42) - Russiagate and the Indictment of James Comey (43:13) - Perjury and Obstruction Charges: The Virginia Trial Dilemma (43:51) - The Durham Investigation: Unveiling Corruption (46:28) - Post-Durham Report Revelations (59:04) - Ukraine Conflict: Provoked or Unprovoked? –Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previous

Lin Yang is a professor of computer science at UCLA. Recently, he and his collaborator built an AI pipeline using commercial models such as Gemini, ChatGPT, and Grok that performed at the gold medal level on International Mathematics Olympiad problems. Steve and Lin discuss this research, which relies on "verifier-refiner" LLM instances and large token budgets to reliably solve difficult problems. They discuss how these methods can be used to advance AI for scientific research, legal analysis, and complex document processing.https://github.com/lyang36/IMO25/blob/main/IMO25.pdfhttps://x.com/hsu_steve/status/1948189075707469942Chapter markers:(00:00) - AIs Win Math Olympiad Gold: Prof. Lin Yang (UCLA) – #97 (00:57) - Prof. Lin Yang, UCLA (04:27) - Journey from Physics to Computer Science: 2 PhDs (11:15) - Transition to AI from Theoretical CS (13:16) - AI Pipeline Math Olympiad: Gold Medal! (28:23) - Probability Amplification (29:00) - Applications in Industry and Legal Analysis (29:58) - Challenges in Model Rea

Zixuan Li is Director of Product and genAI Strategy at Z.ai. He was educated at Renmin and Tsinghua University in China, and at MIT and Carnegie Mellon. Z.ai has released frontier open source LLMs but is largely unknown in the West except among AI experts. Steve and Zixuan discuss the AI race from the perspective of a startup in Beijing.https://chat.z.ai/Follow Z.AI on X: @Zai_orgChapter markers:(00:00) - Introduction and Guest Background (05:14) - Z.ai's Evolution and Challenges (10:37) - AI Model Comparison and Industry Insights (34:04) - Pragmatic Views on AGI in China (35:51) - Specialized Models and Scientific Contributions (39:02) - AI Chips and Model Training in PRC (50:54) - Open Source AI and Future Predictions –Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Orego

This episode is a co-release with the Seeking Truth From Facts podcast: https://substack.com/@seekingtruthfromfactsThe theme of this episode derives from Lenin:“There are decades where nothing happens; and there are weeks when decades happen.” ― Vladimir Ilyich Lenin Steve and Alf discuss:(00:00) - Introduction (01:32) - China Victory Day Parade and new military technology (12:27) - The SCO summit and its implications (20:24) - Modi's presence and the prospect of a Sino-Indian rapprochement (25:00) - Trump's South Asian blunder? (32:14) - The Alaska Summit and the chances of peace (40:01) - Israel's loss of popular support on both the left and the right (46:12) - Bipolarity or multipolarity? –Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (Sup

Kyle Chan is a Postdoctoral Research Associate and Lecturer in Sociology at Princeton University. His research focuses on industrial policy, clean technology, and infrastructure with a regional focus on China and India. He is currently working on a book on Chinese industrial policy that aims to explain how China came to dominate certain industries today that had originally been led by the US, Japan, and other industrialized nations. These industries include electric vehicles, solar, high-speed rail, and consumer electronics. The book will describe the wide range of industrial policy tools used in China and their ongoing efforts in other industries, such as semiconductors and biotechnology.Kyle Chan writes a popular newsletter called High Capacity on industrial policy, clean technology, and infrastructure, particularly in China and India.Personal website: https://www.kyleichan.com/NYT op-ed: https://www.nytimes.com/2025/05/19/opinion/china-us-trade-tariffs.htmlLu Feng interview: https://www.high-capacity.com/p

Dr. Joleen Liang is Co-founder of Squirrel AI, which pioneered adaptive learning at scale, first in China and now in the US. By 2021 its technology had served over 60,000 public schools in 1,200 cities across Asia. Squirrel AI has implemented large knowledge graphs mapping out the main concepts in the K-12 math, science, and language curriculum. The Squirrel learning tablet actively observes student behavior (including eye-tracking during video lessons) and adapts its presentation and testing to individual learning patterns.Chapter markers:(00:00) - Joleen Liang: Co-Founder of Squirrel AI (02:14) - Squirrel AI: Beginnings and scale (14:44) - AI vs Human Teachers (33:51) - Learning environment: tablet, headphones, human supervisors/analysts (51:11) - Challenges and Opportunities in the US Market Music used with permission from Blade Runner Blues Livestream improvisation by State Azure.–Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State Uni