Ois Podcast

If ophthalmology clinical trials were burgers, mitomycin would be the mustard at the table of every U.S. restaurant with a burger on the menu.*Using this analogy, Mitsol, developed and manufactured by Mobius Therapeutics, is the only FDA-approved mitomycin-c “mustard” formulation with an ophthalmic indication.In reality, the mitomycin story in ophthalmology is more complicated than that, says Ed Timm, Founder, Chairman, and CEO of Mobius Therapeutics.Mitomycin-c is used by ophthalmologists to prevent scarring during surgery. Before the FDA approved Mitosol, surgeons would have to obtain a formulation of the antimetabolite from a compounding pharmacy. Because of its instability, the effectiveness of off-label use could vary.All that changed with the arrival of Mitosol, which is a standardized product that requires no refrigeration, no light-shielding, and has a 24-month shelf life.Unfortunately, ophthalmologists still have to develop off-label formulations of other products for use during surgery, which leads