Dental Implant Practices

INDICATION: KOVANAZE is indicated for regional anesthesia when performing a restorative procedure on Teeth 4-13 and A-J in adults and children who weigh 40 kg or more. Patients may not experience the same sensations of numbness or tingling of the lips and cheeks associated with injectable anesthetics. Kovanaze provides regional anesthesia with 96% efficacy in teeth #5-12, 64% in #4 and #13*, therefore Kovanaze offers a needle-free alternative to the majority of anterior maxillary injections. Active Pharmaceutical Ingredients (APIs)Kovanaze® is comprised of two well-known and well-established pharmaceuticals administered as a nasal spray. Tetracaine hydrochloride, the active pharmaceutical, is an ester local anesthetic that blocks sodium ion channels required for the initiation and conduction of neuronal impulses. Oxymetazoline hydrochloride is a sympathomimetic that exerts its local decongestant effects in the nose by stimulating adrenergic receptors, thus eliciting vasoconstriction of dilated arterioles and