Pushing The Limits

A single gene that reverses ageing by over 13 years without activating pluripotency or cancer risk? Shift Bioscience may have cracked the code with SB000, an AI-discovered gene that could revolutionise how we approach ageing, rejuvenation, and gene therapy. In this detailed breakdown, Lisa Tamati, longevity coach, biohacker, and host of the Longevity & Lifestyle podcast Pushing The Limits, explores how SB000 was discovered using cutting-edge AI and transcriptomic ageing clocks, what it actually does at the cellular level, and what this means for the future of safe, targeted anti-aging interventions. What you’ll learn in this episode: How cell age reversal has become a real possibility Why Yamanaka factors (OSKM) carry cancer risk How Shift Bioscience used AI to simulate 562 million gene combinations What makes SB000 unique as a “transcriptomic rejuvenator” The therapeutic potential of SB000 in reversing ageing safely Why this matters for the future of biohacking, longevity science, and gene th