Neuro Experience

You don’t need expensive biohacking tech to fix your brain. On this episode of the Neuro Experience Podcast, neurophysiologist Louisa Nicola reveals how deep sleep, oxygen (VO2 max), and strength training can clear brain fog, sharpen focus, and protect against cognitive decline. Learn practical, science-backed strategies to optimize your brain, think faster, and live longer. Sponsors: David Protein - It's got no junk, no fake health claims, just a smart science-backed snack that supports lean muscle, appetite control, and recovery. Buy 4 cartons and get the 5th one for free. Just go to davidprotein.com/neuro. KetoneIQ: the cleanest ketones I have ever had for long sustaining energy: Visit https://ketone.com/NEURO for 30% OFF your subscription order Goodwipes - If you want to upgrade your restroom ritual with good wipes, go to goodwipes.com, use code NEURO if you're shopping for them online.  The Neuro Athletics Newsletter Instagram: @louisanicola_Twitter : @louisanicola_YouTube: @Louisa NicolaThe Neuro Experi

Dr. Matt Kaeberlein is one of the world’s most respected scientists in the field of aging biology. In this episode, we unpack the real science of longevity — from mTOR inhibition and rapamycin to calorie restriction, biomarkers of aging, and what most people get wrong about lifespan vs healthspan. We go beyond the hype to ask: What actually works? What’s still theoretical? And where is the frontier of human aging research heading? Topics we cover: The biology of aging: mTOR, autophagy, senescence Rapamycin in humans: What we know and don’t Why extending healthspan matters more than living longer Matt’s views on supplements, diet, and biomarkers The most misunderstood concepts in anti-aging Referenced studies include: Dog Aging Project Interventions Testing Program Rapamycin human trial data *** I’m Louisa Nicola — clinical neuophysiologist — Alzheimer’s prevention specialist — founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitiv

Dr. Matt Kaeberlein is a globally recognized expert on the biology of aging and recurring on The Neuro Experience. In this episode, Matt explains his research findings on nutrition as it relates to aging and longevity, including his opinions on the fastest growing "longevity" supplements on the market. Sponsors: BonCharge- Get 15% off any product when you visit https://boncharge.com/ Momentous – Science-backed supplements trusted by elite athletes and experts. Whether you’re looking to improve recovery, performance, or overall wellness, Momentous has you covered. Use code NEURO for 20% off your order: https://www.livemomentous.com/neuro The Neuro Athletics Newsletter Instagram: @louisanicola_Twitter : @louisanicola_YouTube: @Louisa NicolaThe Neuro Experience Podcast is proud to have hosted: Dr Andrew Huberman, Dr Gabrielle Lyon, Dr Layne Norton, Thomas DeLauer, Shawn Stevenson, Dr. Rocio Salas-Whalen, Saad Alam, Uma Naidoo, Dr. Lanna Cheuck, Angela Lee Pucci, Jillian Turecki, Dr. Jordan Feigenbaum, Dr. Darren

It’s becoming harder to ignore: much of what we’ve been taught about food is outdated, oversimplified, or flat-out wrong. In this episode, I’m joined by Professor Tim Spector—renowned epidemiologist, gut microbiome expert, and founder of ZOE—to explore how the bacteria living inside us shape everything from chronic disease and metabolism to mood, menopause, and Alzheimer’s. We dive into why calorie counting fails, why probiotics might be useless, and how your gut could be the root of your brain fog, fatigue, and inflammation. Tim’s work is shaking up nutrition science and forcing us to rethink what “healthy” really means. This conversation will challenge the rules you’ve lived by—and show you how to eat for your biology, not someone else’s. *** I’m Louisa Nicola — clinical neurophysiologist — Alzheimer’s prevention specialist — founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention

What if the key to preventing chronic disease, Alzheimer’s, and even depression lies not in your genes—but in your gut? In this groundbreaking conversation, Louisa Nicola sits down with world-renowned epidemiologist and microbiome expert Professor Tim Spector (MD, King's College London, co-founder of ZOE) to unpack decades of research on the gut microbiome, nutrition, and how it shapes nearly every system in the body—including the brain. You'll learn: Why identical twins with the same DNA can develop completely different diseases How gut microbes regulate immune responses, neurochemicals like GABA and serotonin, and even GLP-1 The emerging connection between gut health and Alzheimer’s disease, stroke, and mood disorders Why probiotics often don’t work—and what to eat instead How menopause radically changes metabolism and gut diversity What 250,000+ people taught Tim about personalized nutrition and energy levels The 6 rules Tim lives by to radically improve gut (and brain) health Whether you're a clin

Studies: https://pubmed.ncbi.nlm.nih.gov/40395689/ https://www.mdpi.com/2072-6643/14/5/921 https://jissn.biomedcentral.com/articles/10.1186/s12970-017-0173-z *** A huge thank you to my sponsors for supporting this episode. Check them out and enjoy exclusive discounts: Hone Health – Take control of your hormones with at-home testing designed specifically for men. Get personalized insights and expert guidance to optimize your health and performance. Learn more at: https://honehealth.com/ Momentous – Science-backed supplements trusted by elite athletes and experts. Whether you’re looking to improve recovery, performance, or overall wellness, Momentous has you covered. Use code NEURO for 20% off your order: https://www.livemomentous.com/neuro Troscriptions – Unlock your cognitive potential with precision-dosed nootropics developed by medical experts. Whether you need more focus, clarity, or energy, Troscriptions offers innovative solutions. - Get 10% off: https://troscriptions.com/NEURO - https://troscripti

Today,  I sit down with Dr. Nick Fabiano, MD, a resident psychiatrist, to explore the powerful connection between creatine supplementation and depression. We dive deep into current scientific evidence discussing how creatine, typically known for its athletic performance benefits, might significantly improve mental health and depressive symptoms.  Dr. Fabiano provides an overview of how creatine impacts brain chemistry, energy metabolism, and mood regulation. Whether you're a clinician looking for novel therapeutic approaches, someone battling depressive symptoms, or simply interested in cutting-edge mental health research, this episode offers valuable insights. Don't miss this fascinating conversation on creatine's potential role in mental health! Key Topics: What is creatine and how does it affect the brain? Clinical evidence linking creatine supplementation to improved depressive symptoms Optimal creatine dosing for mental health benefits Potential mechanisms underlying creatine's antidepressant effects

What if one simple change could slash your Alzheimer’s risk by 36%? In Part 4 of A Woman’s Guide to Alzheimer’s Disease, I uncover the hidden brain dangers of sleep loss, especially for women in perimenopause and menopause. You’ll learn why disrupted sleep isn’t just exhausting, it’s accelerating cognitive decline. I’ll break down the science of the glymphatic system, the critical role of estrogen and progesterone in REM and deep sleep, and the exact strategies I use to optimize sleep quality. From hormone balance and temperature hacks to supplements and tech, this episode is your complete guide to protecting your brain overnight. Don’t let sleep sabotage your future, because your brain depends on it. SponsorsA huge thank you to my sponsors for supporting this episode. Check them out and enjoy exclusive discounts:David Protein - It's got no junk, no fake health claims, just a smart science-backed snack that supports lean muscle, appetite control, and recovery. Buy 4 cartons and get the 5th one for free. Just

I'm excited to share my conversation with Stuart Phillips, where we dive deep into muscle building science - a topic that generates endless debate on social media. As someone who struggles with gaining muscle despite consistent training, I was shocked when Dr. Christopher Gardner told me muscle growth is "10% nutrition and 90% exercise." This contradicted everything I thought I knew, so I had to bring in Stu - widely considered the foremost expert on muscle development - to separate fact from fiction. The most fascinating insight for me was discovering that effective muscle building can happen across a wide range of repetition schemes - from as low as 3 reps to as high as 25 reps per set. This challenges the rigid "strength/hypertrophy/endurance" continuum that's dominated fitness advice for decades. Subscribe to The Neuroscience Experience for more conversations at the intersection of brain science and performance. I'm committed to bringing you evidence-based insights that you can apply to your own health jo

Why are women twice as likely to develop Alzheimer’s disease—especially during and after menopause? The answer goes far beyond age, and what I reveal in this episode might change how you think about your brain forever. In Part 3 of A Woman’s Guide to Alzheimer’s Disease, I uncover the hidden hormonal and genetic factors that put women at greater risk—and the steps you must take before symptoms ever begin. I’ll walk you through the six most powerful prevention strategies, the critical tests your doctor probably hasn’t mentioned, and the one conversation that could completely reshape your cognitive future. SponsorsA huge thank you to my sponsors for supporting this episode. Check them out and enjoy exclusive discounts:Branch Basics - That’s 15% off your New Branch Basics Premium Starter Kit at BranchBasics.com with promo code NEURO. Make the change today—because you and your family deserve better.Momentous – Science-backed supplements trusted by elite athletes and experts. Whether you’re looking to improve reco

In this conversation with Dr. Christopher Gardner, we challenge what might be one of nutrition science's most pervasive myths—that we need massive amounts of protein to build muscle and maintain health. You might recognize Dr. Gardner from the popular Netflix docuseries featuring his groundbreaking identical twin study, where he explored how different diets affect our bodies. We talk about the evidence behind protein requirements, diet quality versus macronutrient ratios, and a framework for sustainable eating that prioritizes both nutrition and taste. We also discuss his DIETFIT study and SWAP-MEAT trial, which challenge conventional wisdom about weight loss diets and plant-based alternatives. The most fascinating insight for me was learning that muscle growth depends approximately 90% on workout stimulus and less than 10% on protein intake, completely contradicting the protein-obsessed fitness culture we're immersed in. Dr. Gardner's research shows the average American already consumes 1.2g/kg of protein d

In this conversation with Dr. Christopher Gardner, we debunk a common nutrition myth—that we need massive protein to build muscle. You might know Dr. Gardner from his twin study featured on Netflix, which explores how diets affect our bodies. We discuss protein requirements, diet quality, and sustainable eating. Plus, Dr. Gardner reveals insights from his DIETFITS Study and SWAP-MEAT trial, challenging conventional views on weight loss and plant-based diets. For science-backed nutrition insights, this conversation cuts through the hype and offers strategies that might change how you think about protein and diet. If you're interested in evidence-based nutrition that cuts through industry hype, this conversation provides scientific clarity and actionable strategies that might change how you think about protein and diet quality. Subscribe to The Neuro Experience for more evidence-based health insights. SponsorsA huge thank you to my sponsors for supporting this episode. Check them out and enjoy exclusive discoun

In this conversation with Dr. Heather Sandison, we explore what I consider to be one of medicine's most significant misunderstandings—that Alzheimer's disease, particularly in women, is an unstoppable fate. We examine the evidence behind cognitive decline, hormones, lifestyle interventions, and a framework for preventing and even reversing what was once considered irreversible. If you're interested in making evidence-based decisions about your brain health, understanding why traditional approaches have failed, or learning about the powerful role of lifestyle interventions in cognitive function, this episode provides both the scientific rationale and actionable strategies you need. Subscribe to The Neuroscience Experience for more conversations that challenge conventional thinking about brain health. I'm committed to bringing you insights that transform how we approach cognitive aging and performance.  SponsorsA huge thank you to my sponsors for supporting this episode. Check them out and enjoy exclusive disco

I'm excited to share my conversation with Dr. Scott Sherr, where we dive deep into methylene blue - a compound you've probably seen all over social media lately (those blue tongues!). As someone whose primary research focuses on Alzheimer's disease, I was fascinated to explore the science behind this molecule that dates back to the 1870s and was actually the first drug registered with the FDA in 1897.  The most fascinating insight for me was learning how methylene blue can serve as an electron acceptor in our mitochondria - essentially functioning as a substitute for oxygen when our cells are under stress. This explains why it shows promise for everything from traumatic brain injury to cognitive enhancement and even as a potential alternative to stimulant medications.   If you're interested in optimizing brain performance, understanding mitochondrial health, or simply curious about this blue compound that's suddenly everywhere, this episode provides both the scientific foundation and practical applications yo

Alzheimer’s doesn’t just “happen” later in life—it’s a slow, silent process that can begin decades before symptoms appear. In this solo episode, we challenge the myth that Alzheimer’s is purely genetic, and break down what the science really says about your risk. I explore the role of the APOE4 gene, how it interacts with lifestyle and metabolic health, and why women—especially during and after menopause—may face a unique vulnerability. Most importantly, I introduce three cutting-edge blood tests that can detect the earliest signs of Alzheimer’s, long before memory loss sets in. We’ll also talk prevention: from blood sugar and insulin resistance to inflammation, hormone balance, and brain energy metabolism—everything you can start doing right now to safeguard your cognitive future. This is more than a conversation about Alzheimer’s—it’s a roadmap for taking control of your brain health. SponsorsA huge thank you to my sponsors for supporting this episode. Check them out and enjoy exclusive discounts:ZocDoc – F

Alzheimer’s doesn’t just “show up” one day - it starts decades earlier. The good news? Your brain health is in your hands. This is Part 1 of a 10-part series where I’ll be breaking down everything you need to know about brain health, cognitive function, and Alzheimer’s prevention. In this episode, I’m explaining how your brain actually works, what affects memory and cognition, and the biggest factors that influence Alzheimer’s risk. I’ll break down the science of neurons, blood flow, and mitochondria—so you can take action now to keep your brain sharp for life. *** A huge thank you to my sponsors for supporting this episode. Check them out and enjoy exclusive discounts: ZocDoc – Finding a great doctor has never been easier. With ZocDoc, you can browse top-rated physicians, read real patient reviews, and book appointments online - all in one place. Get started here: https://www.zocdoc.com/neuro Hone Health – Take control of your hormones with at-home testing designed specifically for men. Get personalized

Testosterone is often misunderstood as a male-exclusive hormone, but did you know that women have four times more testosterone than estrogen? In this episode, I sit down with leading urologist and sexual health expert Dr Rena Malik to uncover the critical role testosterone plays in cognitive function, energy levels, muscle strength, and overall well-being in women.We explore:• The misunderstood role of testosterone in female physiology• Why testosterone deficiency is more common than you think – and how to identify it• The impact of stress, sleep, and modern lifestyles on hormonal balance• The link between testosterone and brain fog, motivation, and libido• Why resistance training is essential for hormonal health• Medical vs. natural interventions – from supplementation to lifestyle strategiesWith emerging research highlighting the intricate relationship between hormones and long-term cognitive and metabolic health, this conversation is a must-listen for anyone looking to optimise longevity, vitality, and per

In today's episode I am kicking off a 10-part series, "Women's Guide to Alzheimer's Disease," focusing on understanding the complexities of the brain. Delve into the basics of neurons, synaptic connections, and the essential role of vascular health in cognitive function.  Discover how lifestyle factors contribute to Alzheimer's and the critical window for intervention.  Explore key elements like mitochondrial function and the APOE4 gene's impact. With insights into brain health and disease prevention, this episode lays the groundwork for optimizing cognitive performance and demystifying Alzheimer's. Sponsors ZocDoc: https://www.zocdoc.com/neuroMomentous - Use code NEURO to get 20% off your order - https://www.livemomentous.com/neuro Timestamps 0:00 Understanding the Brain's Role in Alzheimer's Disease3:55 Momentous Supplements: Purity, Potency, and Safety Guaranteed5:15 Streamlining Doctor Appointments with Zocdoc6:38 The Brain's Vascular Health and Its Link to Alzheimer's9:27 Understanding Alzheimer's Diseas

Is exercise the key to cancer prevention? In this episode of The Neuro Experience Podcast, I sit down with Dr. Inigo San Millan, a world-renowned expert in metabolism, mitochondrial function, and cancer research. We break down the science behind Zone 2 training, how elite athletes unlock metabolic advantages, and why skeletal muscle may be the ultimate defense against disease.

Dr. Inigo San Milan: Leading Expert in Metabolism, Exercise Physiology, and Cancer Research Dr. Inigo San Milan is a globally recognized expert in metabolic health, exercise science, Zone 2 training, mitochondrial function, and cancer metabolism. His groundbreaking research has transformed the understanding of lactate, highlighting its role not just in athletic performance but also in metabolic diseases, cancer progression, and longevity. As a strong advocate of Zone 2 training, Dr. San Milan has demonstrated how it boosts mitochondrial efficiency, improves endurance, enhances fat metabolism, and supports overall healthspan. His pioneering approach explores cancer treatment through metabolic optimization, shifting the focus from traditional gene-targeted therapies to cellular energy balance and metabolic interventions. Dr. San Milan’s work provides a science-backed strategy for disease prevention, peak performance, and longevity through targeted metabolic conditioning. Sponsors:ZocDoc: https://www.zocdoc.com/