Corconsult Rx: Evidence-based Medicine And Pharmacy

On this episode, we review the recently published CLEAR-outcomes trial that was looking at bempedoic acid's (Nexletol) ability to lower the risk of CV events in patients who were unable to tolerate statins at their recommended doses. While recording this episode, we used the trial summary written by Dr. Alex Poppen, PharmD who is the author/owner of the book High-Powered Medicine: Landmark Clinical Trial Reviews. To see all of the study summaries that he has available, check out his website below: https://highpoweredmedicine.com/ Thanks for listening! We want to give a big thanks to our main sponsor Pyrls. Try out their drug information app today. Visit the website below for a free trial: www.pyrls.com/corconsultrx If you want to support the podcast, check out our Patreon account. Subscribers will have access to all previous and new pharmacotherapy lectures as well as downloadable PowerPoint slides for each lecture. You can find our account at the website below:  www.patreon.com/corconsultrx If you have any q

On this episode, we review the treatment and management of various types of anemia. We discuss iron-deficiency anemia, B-12 and folate dificiency anemia, anemia due to CKD, anemia due to chronic disease (inflammation), and aplastic anemia.  Cole and I are happy to share that our listeners can claim ACPE-accredited continuing education for listening to this podcast episode! We have continued to partner with freeCE.com to provide listeners with the opportunity to claim 1-hour of continuing education credit for select episodes. For existing Unlimited (Gold) freeCE members, this CE option is included in your membership benefits at no additional cost! A password, which will be given at some point during this episode, is required to access the post-activity test. To earn credit for this episode, visit the following link below to go to freeCE's website: https://www.freece.com/ If you’re not currently a freeCE member, we definitely suggest you explore all the benefits of their Unlimited Membership on their website an

On this episode we cover three different topics that have been in the medical news lately. First, we compare/contrast the blood pressure goals that were published by the American College of Physicians with other prominent hypertension guidelines. Second, we discuss the semaglutide "side effect" that has been coined Ozempic Face. Finally, Cole reviews some literature surrounding the health benefits of potatoes. Thanks for listening! We want to give a big thanks to our main sponsor Pyrls. Try out their drug information app today. Visit the website below for a free trial: www.pyrls.com/corconsultrx If you want to support the podcast, check out our Patreon account. Subscribers will have access to all previous and new pharmacotherapy lectures as well as downloadable PowerPoint slides for each lecture. You can find our account at the website below:  www.patreon.com/corconsultrx If you have any questions for Cole or me, reach out to us on any of the following: Text - 415-943-6116 Mike - mcorvino@corconsultrx.com Co

On this episode we review typical (first generation) and atypical (second generation) antipsychotics. We discuss receptor signaling, various adverse effects, and specific clinical pearls for the individual medications in the antipsychotic class.  Cole and I are happy to share that our listeners can claim ACPE-accredited continuing education for listening to this podcast episode! We have continued to partner with freeCE.com to provide listeners with the opportunity to claim 1-hour of continuing education credit for select episodes. For existing Unlimited (Gold) freeCE members, this CE option is included in your membership benefits at no additional cost! A password, which will be given at some point during this episode, is required to access the post-activity test. To earn credit for this episode, visit the following link below to go to freeCE's website: https://www.freece.com/ If you’re not currently a freeCE member, we definitely suggest you explore all the benefits of their Unlimited Membership on their webs

On this episode, we discuss dosing antihypertensives at bedtime compared to the morning and if it impacts patient outcomes. We review the MAPEC, Hygia, and TIME studies as well as other editorials on this debated topic. Cole and I are happy to share that our listeners can claim ACPE-accredited continuing education for listening to this podcast episode! We have continued to partner with freeCE.com to provide listeners with the opportunity to claim 1-hour of continuing education credit for select episodes. A password, which will be given at some point during this episode, is required to access the post-activity test. To earn credit for this episode, visit the following link below to go to freeCE's website: www.freece.com For existing Unlimited freeCE members, this CE option is included in your membership benefits at no additional cost! Members can simply follow the link above to take the post-test and evaluation for this activity. If you’re not currently a freeCE member, we definitely suggest you explore all th

On this episode we discuss the new drugs that have been approved in 2023 so far. We review Leqembi (lecanemab-irmb) injection for Alzheimer's disease, Airsupra (albuterol and budesonide) inhalation for as-needed use in asthma, and Brenzavvy (bexagliflozin) for type 2 diabetes. We also mention Rykindo (risperidone) ER injection, but we didn't go into much detail since we've gone over risperidone in previous episodes.  Thanks for listening! We want to give a big thanks to our main sponsor Pyrls. Try out their drug information app today. Visit the website below for a free trial: www.pyrls.com/corconsultrx If you want to support the podcast, check out our Patreon account. Subscribers will have access to all previous and new pharmacotherapy lectures as well as downloadable PowerPoint slides for each lecture. You can find our account at the website below:  www.patreon.com/corconsultrx If you have any questions for Cole or me, reach out to us on any of the following: Text - 415-943-6116 Mike - mcorvino@corconsultrx

On this episode, we discuss the pharmacotherapy options for managing obsessive compulsive disorder (OCD). We based our discussion on the treatment algorithm created by Dr David Osser. All of Dr. Osser's work with the Psychopharmacology Algorithms Project at the Harvard South Shore Psychiatry Residency Training Program can be found at the following website: https://psychopharm.mobi/algo_live/# Cole and I are happy to share that our listeners can claim ACPE-accredited continuing education for listening to this podcast episode! We have continued to partner with freeCE.com to provide listeners with the opportunity to claim 1-hour of continuing education credit for select episodes. To earn credit for this episode, visit the following link below to reach the post-activity test for this episode: List of podcasts on freeCE.com For existing Unlimited freeCE members, this CE option is included in your membership benefits at no additional cost! Members can simply follow the link above to take the post-test and evaluatio

On this episode, Cole and I review some of the updates that were published in the 2023 American Diabetes Association guidelines. Cole and I are happy to share that our listeners can claim ACPE-accredited continuing education for listening to this podcast episode! We have continued to partner with freeCE.com to provide listeners with the opportunity to claim 1-hour of continuing education credit for select episodes. To earn credit for this episode, visit the following link below to reach the post-activity test for this episode: https://legacy.freece.com/Home/CECataLogPodcast For existing Unlimited freeCE members, this CE option is included in your membership benefits at no additional cost! Members can simply follow the link above to take the post-test and evaluation for this activity. Use the password SLEEP (all caps) to unlock the post-test for this episode. But if you’re not currently a freeCE member, we definitely suggest you explore all the benefits of their Unlimited Membership on their website and earn C

Below is the patient case information: 63-year-old white male. Problem List Bipolar II disorder Insomnia Epilepsy (tonic-clonic seizures) Dyslipidemia/hypertriglyceridemia Hypertension Recent weight gain History of hyponatremia  Diabetes type 2(controlled) Medications Clonazepam 2 mg QHS Risperdal 2 mg twice daily Carbamazepine 200 mg twice daily Divalproex DR 500 mg three times daily Levetiracetam 1000 mg twice daily Losartan 100 mg daily HCTZ 25 mg daily Atorvastatin 40 mg daily Fenofibrate 48 mg daily Metformin ER 500 mg twice daily Vitals: Blood pressure is currently 144/86 mmHg Lipids: LDL-C: 98 Triglycerides: 245 (down from 423 4 months ago) CMP: Na+: 133 K+: 4.1 eGFR: 95 All others WNL as well CBC: Hgb: 10:1 g/dL MCV: 73 Ferritin: 17 A1c: 6.9% Current Appointment The patient has seen multiple neuro and psych providers over the last year.  The R­­isperdal and divalproex were for the bipolar II disorder. The patient is experiencing depression symptoms. His family notes that he has also been uncharacteris

On this episode, we discuss the management of insomnia disorder. We review the criteria necessary for an insomnia disorder diagnosis. We then compare and contrast the pharmacotherapy options such as non-benzodiazepine hypnotics, benzodiazepines, anti-depressants, orexin receptor antagonists, and more.  Cole and I are happy to share that our listeners can claim ACPE-accredited continuing education for listening to this podcast episode! We have continued to partner with freeCE.com to provide listeners with the opportunity to claim 1-hour of continuing education credit for select episodes. To earn credit for this episode, visit the following link below to reach the post-activity test for this episode: https://legacy.freece.com/Home/CECataLogPodcast For existing Unlimited freeCE members, this CE option is included in your membership benefits at no additional cost! Members can simply follow the link above to take the post-test and evaluation for this activity. Use the password SLEEP (all caps) to unlock the post-t

On this episode, we discuss the various therapeutic options for managing a patient with chronic pain. We discuss nonpharmacological options, anti-inflammatory medications, and other non-opioid pharmacological options. Then, we compare and contrast some of the commonly used opioids and discuss some of the nuances/clinical pearls for individual opioids. Cole and I are happy to share that our listeners can claim ACPE-accredited continuing education for listening to this podcast episode! We have continued to partner with freeCE.com to provide listeners with the opportunity to claim 1-hour of continuing education credit for select episodes. To earn credit for this episode, visit the following link below to reach the post-activity test for this episode: List of podcasts on freeCE.com For existing Unlimited freeCE members, this CE option is included in your membership benefits at no additional cost! Members can simply follow the link above to take the post-test and evaluation for this activity. Use the password PAIN

On this episode, Cole and I review the published treatment algorithm created by Harmony Raylen Abejuela, MD and David Osser, MD. This was part of the Psychopharmacology Algorithm Project at the Harvard South Shore Program. A link to the article on Pubmed is below: Anxiety Algorithm Cole and I are happy to share that our listeners can claim ACPE-accredited continuing education for listening to this podcast episode! We have continued to partner with freeCE.com to provide listeners with the opportunity to claim 1-hour of continuing education credit for select episodes. To earn credit for this episode, visit the following link below to reach the post-activity test for this episode: List of podcasts on freeCE.com For existing Unlimited freeCE members, this CE option is included in your membership benefits at no additional cost! Members can simply follow the link above to take the post-test and evaluation for this activity. Use the password WORRY (all caps) to unlock the post-test for this episode. But if you’re no

On this episode, we review the results that have been reported from the Diuretic Comparison Project (DCP). The point-of-care clinical trial was looking at CV outcomes based on patients using HCTZ vs chlorthalidone. We also discuss the reasons for using indapamide over other thiazide (like) diuretics.  Thanks for listening! We want to give a big thanks to our main sponsor Pyrls. Try out their drug information app today. Visit the website below for a free trial: www.pyrls.com/corconsultrx If you want to support the podcast, check out our Patreon account. Subscribers will have access to all previous and new pharmacotherapy lectures as well as downloadable PowerPoint slides for each lecture. You can find our account at the website below:  www.patreon.com/corconsultrx If you have any questions for Cole or me, reach out to us on any of the following: Text - 415-943-6116 Mike - mcorvino@corconsultrx.com Cole - cswanson@corconsultrx.com Instagram and other social media platforms - @corconsultrx This podcast reviews c

On this episode, we compare and contrast oral medications that can be used to manage patients with type-2 diabetes. We review metformin, SGLT2 inhibitors, oral semaglutide, sulfonylureas, TZDs, and more.  Cole and I are happy to share that our listeners can claim ACPE-accredited continuing education for listening to this podcast episode! We have continued to partner with freeCE.com to provide listeners with the opportunity to claim 1-hour of continuing education credit for select episodes. To earn credit for this episode, visit the following link below to reach the post-activity test for this episode: Oral DM2 Meds For existing Unlimited freeCE members, this CE option is included in your membership benefits at no additional cost! Members can simply follow the link above to take the post-test and evaluation for this activity. Use the password DMMEDS (all caps) to unlock the post-test for this episode. But if you’re not currently a freeCE member, we definitely suggest you explore all the benefits of their Unlim

On this episode, we review the management of amyotrophic lateral sclerosis (ALS). We discuss riluzole, edaravone, and sodium phenylbutyrate-taurursodiol (Relyvrio) that gained FDA approval in September 2022.  Thanks for listening! We want to give a big thanks to our main sponsor Pyrls. Try out their drug information app today. Visit the website below for a free trial: www.pyrls.com/corconsultrx If you want to support the podcast, check out our Patreon account. Subscribers will have access to all previous and new pharmacotherapy lectures as well as downloadable PowerPoint slides for each lecture. You can find our account at the website below:  www.patreon.com/corconsultrx If you have any questions for Cole or me, reach out to us on any of the following: Text - 415-943-6116 Mike - mcorvino@corconsultrx.com Cole - cswanson@corconsultrx.com Instagram and other social media platforms - @corconsultrx This podcast reviews current evidence-based medicine and pharmacy treatment options. This podcast is intended to be

On this episode, we discuss chronic coronary syndromes, and we focus primarily on the treatment of acute episodes of angina.  Cole and I are happy to share that our listeners can claim ACPE-accredited continuing education for listening to this podcast episode! We have continued to partner with freeCE.com to provide listeners with the opportunity to claim 1-hour of continuing education credit for select episodes. To earn credit for this episode, visit the following link below to reach the post-activity test for this episode: Chronic Coronary Syndromes For existing Unlimited freeCE members, this CE option is included in your membership benefits at no additional cost! Members can simply follow the link above to take the post-test and evaluation for this activity. Use the password CORONARY (all caps) to unlock the post-test for this episode. But if you’re not currently a freeCE member, we definitely suggest you explore all the benefits of their Unlimited Membership on their website and earn CE for listening to th

On this episode, we discuss the management of acute and chronic atrial fibrillation. We review the various pharmacotherapy options, compare rate control versus rhythm control, and discuss other clinic trials that support the newest treatment guidelines.  Cole and I are happy to share that our listeners can claim ACPE-accredited continuing education for listening to this podcast episode! We have continued to partner with freeCE.com to provide listeners with the opportunity to claim 1-hour of continuing education credit for select episodes. To earn credit for this episode, visit the following link below to reach the post-activity test for this episode: Managing Atrial Fibrillation For existing Unlimited freeCE members, this CE option is included in your membership benefits at no additional cost! Members can simply follow the link above to take the post-test and evaluation for this activity. Use the password RHYTHM (all caps) to unlock the post-test for this episode. But if you’re not currently a freeCE member,

We are joined by Dr. Wayne Weart to celebrate reaching our 200th episode. We discuss his career as a clinical pharmacist and educator and get his thoughts on the current state of the pharmacotherapy world.  Thanks for listening! We want to give a big thanks to our main sponsor Pyrls. Try out their drug information app today. Visit the website below for a free trial: www.pyrls.com/corconsultrx If you want to support the podcast, check out our Patreon account. Subscribers will have access to all previous and new pharmacotherapy lectures as well as downloadable PowerPoint slides for each lecture. You can find our account at the website below:  www.patreon.com/corconsultrx If you have any questions for Cole or me, reach out to us on any of the following: Text - 415-943-6116 Mike - mcorvino@corconsultrx.com Cole - cswanson@corconsultrx.com Instagram and other social media platforms - @corconsultrx This podcast reviews current evidence-based medicine and pharmacy treatment options. This podcast is intended to be us

On this episode, we review the data that lead to some SGLT-2 inhibitors being used routinely in heart failure. We discuss the initial cardiovascular safety studies that initially showed heart failure benefit in this class. Then we look as some of the newer studies that have looked at empagliflozin and dapagliflozin in heart failure patients (with and without diabetes as a comorbidity). Cole and I are happy to share that our listeners can claim ACPE-accredited continuing education for listening to this podcast episode! We have continued to partner with freeCE.com to provide listeners with the opportunity to claim 1-hour of continuing education credit for select episodes. To earn credit for this episode, visit the following link below to reach the post-activity test for this episode: SGLT-2 Inhibitors in HF For existing Unlimited freeCE members, this CE option is included in your membership benefits at no additional cost! Members can simply follow the link above to take the post-test and evaluation for this act

On this episode, we discuss deucravacitinib tablets (Sotyktu), roflumilast cream (Zoryve), and tapinarof cream (Vtama). All three medications were approved in 2022 and represent new classes of medication for the treatment of plaque psoriasis. We also give a brief overview of the older treatment options that are used for plaque psoriasis as well.  Thanks for listening! We want to give a big thanks to our main sponsor Pyrls. Try out their drug information app today. Visit the website below for a free trial: www.pyrls.com/corconsultrx If you want to support the podcast, check out our Patreon account. Subscribers will have access to all previous and new pharmacotherapy lectures as well as downloadable PowerPoint slides for each lecture. You can find our account at the website below:  www.patreon.com/corconsultrx If you have any questions for Cole or me, reach out to us on any of the following: Text - 415-943-6116 Mike - mcorvino@corconsultrx.com Cole - cswanson@corconsultrx.com Instagram and other social media pl